This project utilizes induced pluripotent stem cell (hiPSC)–derived alveolar type II (iAT2) and type I (iAT1) cells cultured under physiologically relevant air–liquid interface (ALI) conditions to model host–pathogen interactions to study their response to invasive pulmonary mucormycosis. Host receptors and fungal ligands will be identified and their role in fungal pathogenesis determined. We will Identify transcriptional pathways linked to inflammation, epithelial injury, and impaired regeneration.