Publications

Research Articles

Kavaliauskas P, Risteen R, Alkhazraji S, Shirtliff B, Walsh TJ, Ibrahim AS, Bruno VM. Integrin ß4 is a receptor for emerging fungal pathogens from the genera Lomentospora and Scedosporium. PLoS Pathog. 2026 Apr 8;22(4):e1014107. doi: 10.1371/journal.ppat.1014107. PMID: 41950283; PMCID: PMC13061235.

Gu Y, Ibrahim BA, Gebremariam T, Alkhazraji S, Aerts R, Vanbiervliet Y, Lagrou K, Maertens J, Prattes J, Egger M, Dichtl K, Jenks JD, Hoenigl M, Ibrahim AS. Rapid and reliable diagnosis of mucormycosis using colorimetric loop-mediated isothermal amplification. J Clin Microbiol. 2026 Apr 8;64(4):e0179025. doi: 10.1128/jcm.01790-25. Epub 2026 Feb 26. PMID: 41746213; PMCID: PMC13059791.

Pikoulas A, Morianos I, Nidris V, Hamdy R, Intze E, López-López Á, Moran-Garrido M, Muthu V, Halabalaki M, Papaioanou V, Papadovasilaki M, Kyrmizi I, Gu Y, Camunas-Alberca SM, Aerts R, Mercier T, Vanbiervliet Y, Cho SY, Spallone A, Jiang Y, Samonakis D, Kastritis E, Lax C, Tzardi M, Eliopoulos A, Georgila K, Carvalho A, Kurzai O, Rudramurthy SM, Elie C, Lanternier F, Petratos K, Garre V, Drakos E, Maertens J, Bruno VM, Kontoyiannis DP, Barbas C, Soliman SSM, Ibrahim AS, Chamilos G. Albumin orchestrates a natural host defence mechanism against mucormycosis. Nature. 2026 Jan;649(8097):693-702. doi: 10.1038/s41586-025-09882-3. Epub 2026 Jan 7. Erratum in: Nature. 2026 Feb;650(8102):E11. doi: 10.1038/s41586-026-10188-1. PMID: 41501454; PMCID: PMC12804082.

Gu Y, Singh S, Alqarihi A, Alkhazraji S, Gebremariam T, Youssef EG, Liu H, Fan X, Jiang WR, Andes D, Cochrane TR, Schwartz JA, Filler SG, Uppuluri P, Ibrahim AS. A humanized antibody against mucormycosis targets angioinvasion and augments the host immune response. Sci Transl Med. 2025 Mar 12;17(789):eads7369. doi: 10.1126/scitranslmed.ads7369. Epub 2025 Mar 12. PMID: 40073153; PMCID: PMC12020122.

Kavaliauskas P, Gu Y, Hasin N, Graf KT, Alqarihi A, Shetty AC, McCracken C, Walsh TJ, Ibrahim AS, Bruno VM. Multiple roles for hypoxia inducible factor 1-alpha in airway epithelial cells during mucormycosis. Nat Commun. 2024 Jun 20;15(1):5282. doi: 10.1038/s41467-024-49637-8. PMID: 38902255; PMCID: PMC11190229.

Soliman SSM, Baldin C, Gu Y, Singh S, Gebremariam T, Swidergall M, Alqarihi A, Youssef EG, Alkhazraji S, Pikoulas A, Perske C, Venkataramani V, Rich A, Bruno VM, Hotopp JD, Mantis NJ, Edwards JE Jr, Filler SG, Chamilos G, Vitetta ES, Ibrahim AS. Mucoricin is a ricin-like toxin that is critical for the pathogenesis of mucormycosis. Nat Microbiol. 2021 Mar;6(3):313-326. doi: 10.1038/s41564-020-00837-0. Epub 2021 Jan 18. PMID: 33462434; PMCID: PMC7914224.

Alqarihi A, Gebremariam T, Gu Y, Swidergall M, Alkhazraji S, Soliman SSM, Bruno VM, Edwards JE Jr, Filler SG, Uppuluri P, Ibrahim AS. GRP78 and Integrins Play Different Roles in Host Cell Invasion during Mucormycosis. mBio. 2020 Jun 2;11(3):e01087-20. doi: 10.1128/mBio.01087-20. PMID: 32487760; PMCID: PMC7267888.

Cornely OA, Alastruey-Izquierdo A, Arenz D, Chen SCA, Dannaoui E, Hochhegger B, Hoenigl M, Jensen HE, Lagrou K, Lewis RE, Mellinghoff SC, Mer M, Pana ZD, Seidel D, Sheppard DC, Wahba R, Akova M, Alanio A, Al-Hatmi AMS, Arikan-Akdagli S, Badali H, Ben-Ami R, Bonifaz A, Bretagne S, Castagnola E, Chayakulkeeree M, Colombo AL, Corzo-León DE, Drgona L, Groll AH, Guinea J, Heussel CP, Ibrahim AS, Kanj SS, Klimko N, Lackner M, Lamoth F, Lanternier F, Lass-Floerl C, Lee DG, Lehrnbecher T, Lmimouni BE, Mares M, Maschmeyer G, Meis JF, Meletiadis J, Morrissey CO, Nucci M, Oladele R, Pagano L, Pasqualotto A, Patel A, Racil Z, Richardson M, Roilides E, Ruhnke M, Seyedmousavi S, Sidharthan N, Singh N, Sinko J, Skiada A, Slavin M, Soman R, Spellberg B, Steinbach W, Tan BH, Ullmann AJ, Vehreschild JJ, Vehreschild MJGT, Walsh TJ, White PL, Wiederhold NP, Zaoutis T, Chakrabarti A; Mucormycosis ECMM MSG Global Guideline Writing Group. Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium. Lancet Infect Dis. 2019 Dec;19(12):e405-e421. doi: 10.1016/S1473-3099(19)30312-3. Epub 2019 Nov 5. PMID: 31699664; PMCID: PMC8559573.

Gebremariam T, Alkhazraji S, Soliman SSM, Gu Y, Jeon HH, Zhang L, French SW, Stevens DA, Edwards JE Jr, Filler SG, Uppuluri P, Ibrahim AS. Anti-CotH3 antibodies protect mice from mucormycosis by prevention of invasion and augmenting opsonophagocytosis. Sci Adv. 2019 Jun 12;5(6):eaaw1327. doi: 10.1126/sciadv.aaw1327. PMID: 31206021; PMCID: PMC6561750.

Andrianaki AM, Kyrmizi I, Thanopoulou K, Baldin C, Drakos E, Soliman SSM, Shetty AC, McCracken C, Akoumianaki T, Stylianou K, Ioannou P, Pontikoglou C, Papadaki HA, Tzardi M, Belle V, Etienne E, Beauvais A, Samonis G, Kontoyiannis DP, Andreakos E, Bruno VM, Ibrahim AS, Chamilos G. Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species. Nat Commun. 2018 Aug 20;9(1):3333. doi: 10.1038/s41467-018-05820-2. Erratum in: Nat Commun. 2018 Nov 22;9(1):5015. doi: 10.1038/s41467-018-07301-y. PMID: 30127354; PMCID: PMC6102248.