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Translational Immunobiology
Project type
Research
Location
UT MD Anderson Cancer Center
This project serves as a translational bridge, focusing on identifying "immune paralysis" in high-risk patients and evaluating advanced treatment strategies.
Mapping Immune Evasion
Using samples from the program's Clinical Core, researchers are mapping the dynamics of immune exhaustion in cancer patients to determine its prognostic significance.
Synergistic Immunotherapies
The project tests the efficacy of combining standard antifungals with FDA-approved non-cellular immune enhancers, such as immune checkpoint inhibitors (ICIs), cytokines like interferon-gamma (IFN-), and growth factors like GM-CSF.
Multimodal Management
A primary goal is to determine the optimal sequential deployment of anti-virulence agents, antifungals, and host-targeted immunomodulators in clinically relevant models, including those for acute myeloid leukemia (AML).